Desai Lab

Lang, G. I.*, D. P. Rice*, M. J. Hickman, E. Sodergren, G. M. Weinstock, D. Botstein^†, and M. M. Desai^†. Pervasive Genetic Hitchhiking and Clonal Interference in 40 Evolving Yeast Populations. Submitted.
Nicolaisen, L. E. and M. M. Desai. Distortions in Genealogies Due to Purifying Selection. Submitted.
Perron, G. G., L. Whyte, P. J. Turnbaugh, W. P. Hanage, G. Dantas, and M. M. Desai. Functional Characterization of Ancient Antibiotic Resistance. Submitted.
Van Dyken, J. D., M. J. I. Muller, K. M. L. Mack, and M. M. Desai. Spatial Population Expansion Promotes the Evolution of Cooperation in an Experimental Prisoner's Dilemma. Current Biology, in press (2013).
Good, B. H. and M. M. Desai. Fluctuations in Fitness Distributions and the Effects of Weak Linked Selection on Sequence Evolution. Theoretical Population Biology 85:86-102 (2013). [software].
Desai, M. M.*, A. M. Walczak*, and D. S. Fisher. Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations. Genetics 193:565-585 (2013).
Desai, M. M. Statistical Questions in Experimental Evolution. Journal of Statistical Mechanics P01003 (2013).
Nicolaisen, L. E. and M. M. Desai. Distortions in Genealogies Due to Purifying Selection. Molecular Biology and Evolution 29:3589-3600 (2012).
Goyal, S., D. J. Balick, E. R. Jerison, R. A. Neher, B. I. Shraiman, and M. M. Desai. Dynamic Mutation-Selection Balance as an Evolutionary Attractor. Genetics 191:1309-1319 (2012).
Kryazhimskiy, S. K., D. P. Rice, and M. M. Desai. Population Subdivision and Adaptation in Asexual Populations of Saccharomyces cerevisiae. Evolution 66:1931-1941 (2012).
Good, B. H., I. M. Rouzine, D. J. Balick, O. Hallatschek, and M. M. Desai. Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations. PNAS 109:4950-4955 (2012).
Desai, M. M.*, L. E. Nicolaisen*, A. M. Walczak, and J. B. Plotkin. The Structure of Allelic Diversity in the Presence of Purifying Selection. Theoretical Population Biology 81:144-157 (2012).
Walczak, A. M.*, L. E. Nicolaisen*, J. B. Plotkin, and M. M. Desai. The Structure of Genealogies in the Presence of Purifying Selection: A "Fitness-Class Coalescent". Genetics 190:753 (2012).
Desai, M. M. and D. S. Fisher. The Balance Between Mutators and Nonmutators in Asexual Populations. Genetics 188:997-1014 (2011).
Lang, G. I., D. Botstein, and M. M. Desai. Genetic Variation And the Fate of Individual Beneficial Mutations in Asexual Populations. Genetics 188:647-661 (2011).
Weissman, D. W., M. M. Desai, D. S. Fisher, and M. W. Feldman. The Rate at Which Asexual Populations Cross Fitness Valleys. Theoretical Population Biology. 75:286-300 (2009).
Desai, M. M. Reverse Evolution and Evolutionary Memory. Nature Genetics 41:142-3 (2009).
Gresham, D., M. M. Desai, C. M. Tucker, H. T. Jenq, D. A. Pai, A. Ware, C. G. DeSevo, D. Botstein, and M. J. Dunham. The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast. PLoS Genetics 4: e1000303 (2008).
Desai, M. M. and J. B. Plotkin. The Polymorphism Frequency Spectrum of Finitely Many Sites Under Selection. Genetics 180:2175-91 (2008).
Fogle, C. A., J. L. Nagle, and M. M. Desai. Clonal Interference, Multiple Mutations, and Adaptation in Large Asexual Populations. Genetics 180:2163-73 (2008).
Desai, M. M., D. W. Weissman, and M. W. Feldman. Evolution Can Favor Antagonistic Epistasis. Genetics 177:1001-10 (2007).
Desai, M. M. and D. S. Fisher. Beneficial Mutation-Selection Balance and the Effect of Linkage on Positive Selection. Genetics 176:1759-98 (2007).
Desai, M. M., D. S. Fisher, and A. W. Murray. The Speed of Evolution and Maintenance of Variation in Asexual Populations. Current Biology 17:385-94 (2007).
Plotkin, J. B., J. Dushoff, M. M. Desai, and H. B. Fraser. Codon Usage and Selection on Proteins. Journal of Molecular Evolution 63:635-53 (2006).
Thompson, D. A., M. M. Desai, and A. W. Murray. Ploidy Controls the Success of Mutators and Nature of Mutations During Budding Yeast Evolution. Current Biology 16:1581-90 (2006).
Plotkin, J. B., J. Dushoff, M. M. Desai, and H. B. Fraser. Estimating Selection Pressures from Limited Comparative Data. Molecular Biology and Evolution 23:1457-9 (2006).
Desai, M. M. and D. R. Nelson. A Quasispecies on a Moving Oasis. Theoretical Population Biology 67:33-45 (2005).

*Co-first authors
^†Co-senior authors