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Joe Gasper

I was the research technician in the Edwards lab. Since graduating, I continued to take courses at the University, studying Japanese, molecular evolution, and biogeography. My research primarily involves determining possible models of evolution of class II Mhc genes. The main method of obtaining the data is by large scale sequencing of Mhc bearing cosmids, which proves to be useful in sequencing fragments or pseudogenes that otherwise might be missed in Southern blots. During my time in the Edwards lab, we sequenced two cosmids, totaling 71,000 base pairs. Thus far, our data suggested a mixture of evolutionary models of the Mhc gene family, such as the birth and death model and concerted evolution. Below are publications from that time and a figure of a 38,785 bp cosmid. Note the simple repeats and non alu repeats found as well as the Mhc gene and fragment.

Current position at the University of Washington, Seattle

Education:

B.S., Fisheries, University of Washington, 1994.

Publications:

Edwards, S.V., C.M. Hess, J. Gasper, and D. Garrigan. 1999. Toward an evolutionary genomics of the avian Mhc. Immunological Reviews. 167: 119-132.

Edwards, S.V., J. Nusser, J. Gasper. 1999. Characterization and evolution of Mhc genes from non-model organisms, with examples from birds. In Molecular Methods in Ecology, ed. A.J. Baker, in press. Cambridge: Blackwell Scientific.

Edwards, S.,J. Gasper, M. Stone. 1998. Genomics and polymorphism of Agph-DAB1, an Mhc class II B gene in Red-winged Blackbirds ( Agelaius phoeniceus ). Molecular Biology and Evolution. 15: 236-250.

 

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