Christopher Marx


Christopher J. Marx

Associate Professor of Organismic & Evolutionary Biology

Phone: 617-496-8103
Office: 3083 BioLabs, 16 Divinity Ave

Lab Website:

Experimental evolution of microbes to address broad evolutionary and ecological questions and explore the systems-level function and optimization of complex biological networks.

Recent Publications

Chou H-H, Berthet J, and Marx CJ 2009. Fast Growth Increases the Selective Advantage of a Mutation Arising Recurrently during Evolution under Metal Limitation. PLoS Genetics 5(9): e1000652. doi:10.1371/journal.pgen.1000652

Lee, M-C, H-H Chou, and C. J. Marx. 2009. Assymetric, bi-modal tradeoffs during adaptation of Methylobacterium to distinct growth substrates. Evolution 63-11: 2816-2830. doi:10.1111/j.1558-5646.2009.00757.x

Marx, C.J. 2009. Getting in Touch with Your Friends. Science 324: 1150-1151. doi: 10.1126/science.1173088

Vuilleumier S, Chistoserdova L, Lee M-C, Bringel F, Lajus A, Zhou Y, Gourion B, Barbe V, Chang J, Cruveiller S, Dossat C, Gillett W, Gruffaz C, Haugen E, Hourcade E, Levy R, Mangenot S, Muller E, Nadalig T, Pangi M, Penny C, Peyraud R, Robinson D, Roche D, Rouy Z, Saenampechek C, Salvignol G, Vallenet D, Wu Z, Marx CJ, Vorholt JA, Olson MV, Kaul R, Weissenbach J, Medigue C, and Lindstrom ME. 2009. Methylobacterium Genome Sequences: A Reference Blueprint to Investigate Microbial Metabolism of C1 Compounds from Natural and Industrial Sources. PLoS ONE 4(5): e5584. doi:10.1371/journal.pone.0005584

Marx, C.J. 2008. Development of a broad-host-range sacB-based vector for unmarked allelic exchange. BMC Research Notes 1:1. doi:10.1186/1756-0500-1-1

Chain, P. S. G., V. J. Denef, K. Konstantinidis, L. M Vergez, L. Agulló, V. Latorre Reyes, L. Hauser, M. Córdova, L. Gómez, M. González, M. Land, V. Lao, F. Larimer, J. J. LiPuma, E. Mahenthiralingam, S. A. Malfatti, C. J. Marx , J. J. Parnell, A. Ramette, P. Richardson, M. Seeger, D. Smith, T. Spilker, W. J. Sul, T. V. Tsoi, L. E. Ulrich, I. B. Zhulin, and J. M. Tiedje. 2006. Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73 Mbp genome shaped for versatility. Proc. Natl. Acad. Sci. USA 103:15280-15287

Kalyuzhnaya, M. G., N. Korotkova, G. Crowther, C. J. Marx , M. E. Lidstrom, and L. Chistoserdova. 2005. Analysis of gene islands involved in methanopterin-linked C 1 transfer reactions, deduction of novel C 1 transfer genes, and new insights into the evolution of "archaeal" genes in bacteria. J. Bacteriol. 187:4607-4614

Marx, C. J., S. J. Van Dien, and M. E. Lidstrom. 2005. Flux analysis uncovers key role of functional redundancy in formaldehyde pathways. PLoS Biol. 3:e16 [Highlighted in Nature Reviews Microbiology 3:103]

Marx, C. J., J. A. Miller, L. Chistoserdova, and M. E. Lidstrom. 2004. Multiple formaldehyde oxidation pathways in Burkholderia fungorum LB400. J. Bacteriol. 186:2173-2178

Chistoserdova, L., C. Jenkins, M. G. Kalyuzhnaya, C. J. Marx, A. Lapidus, J. T. Staley, and M.E. Lidstrom. 2004. The enigmatic Planctomyces may hold a key to the origins of methanogenesis and methylotrophy. Mol. Biol. Evol. 21:1234-1241


Courses Taught

OEB 100. Evolution in Action

OEB 192. Microbial Evolution

OEB 279. Topics in Microbial Metabolic Systems

OEB 365. Evolution of Microbes


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