Pardis Sabeti, M.D. D.Phil.

Assistant Professor of Organismic and Evolutionary Biology
Center for Systems Biology

Phone: 617-252-1190
E-mail:
Office: Broad Institute of MIT and Harvard, 7 Cambridge Center, Rm 6047

The goals of the Sabeti lab are to study the effect of natural selection on the human genome and the genomes of other organisms and uncover the traits that have emerged to shape these species, and to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci: (1) developing analytical methods to detect and investigate natural selection in the genome of humans and other species, (2) pursuing signals of natural selection in humans to identify their underlying functional trait and the mechanism of evolution (e.g resistance to Lassa fever virus, and hair, sweat, and teeth development), and (3) examining signals of natural selection in pathogens to understand how they rapidly evolve to remain agents of human morbidity and mortality.

Recent Publications

Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, et al. Genome-wide detection and characterization of positive selection in human populations. Nature 2007,449:913-918.

International Haplotype Map Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007,449:851-861.

Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Jr., et al. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet 2007,39:113-119.

Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, et al. Positive natural selection in the human lineage. Science 2006,312:1614-1620.

International Haplotype Map Consortium. A haplotype map of the human genome. Nature 2005,437:1299-1320.

Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, et al. The case for selection at CCR5-Delta32.PLoS Biol 2005. 3:e378

Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 2002,419:832-837.