# Pardis Sabeti Professor of Organismic and Evolutionary Biology Professor of Immunology and Infectious Diseases Institute Member, Broad Institute of MIT and Harvard Howard Hughes Medical Institute Investigator ![Pardis Sabeti smiling, with long light brown hair and black shirt, in front of grey background](/sites/g/files/omnuum6811/files/styles/hwp_4_5__320x400/public/oeb/files/sabeti.jpg?itok=ZotIiNIB) location\_on Northwest Building52 Oxford StreetCambridge, MA 02138 email laptop\_windows [Sabeti Lab](http://sabetilab.org/) Faculty Support: [Michael J. Butts](/people/michael-j-butts) The goals of the Sabeti lab are to study the effect of natural selection on the human genome and the genomes of other organisms and uncover the traits that have emerged to shape these species, and to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci: (1) developing analytical methods to detect and investigate natural selection in the genome of humans and other species, (2) pursuing signals of natural selection in humans to identify their underlying functional trait and the mechanism of evolution (e.g resistance to Lassa fever virus, and hair, sweat, and teeth development), and (3) examining signals of natural selection in pathogens to understand how they rapidly evolve to remain agents of human morbidity and mortality. **Recent Publications** Kamberov YG, S Wang, J Tan, P Gerbault, A Wark, L Tan, Y Yang, S Li, K Tang, H Chen, A Powell, Y Itan, D Fuller, J Lohmueller, J Mao, A Schachar, M Paymer, E Hostetter, E Byrne, M Burnett, AP McMahonb, MG Thomas, DE Lieberman, L Jin, CJ Tabin, BA Morgan, **PC Sabeti**. Modeling human evolution in mice: An adaptive variant of EDAR drives pleiotropic changes in mice and humans. *Cell* 2013 Feb 14;152(4):691-702. PubMed PMID: 23415220. SR Grossman, KG Andersen, I Shlyakhter, S Tabrizi, S Winnicki, A Yen, DJ Park, D Griesemer, EK Karlsson, SH Wong, M Cabili, RA Adegbola, RNK Bamezai, AVS. Hill, FO Vannberg, JL Rinn, 1000 Genomes Project, ES Lander, SF Schaffner, **PC Sabeti**. Identifying Recent Adaptations in Large-scale Genomic Data. *Cell* 2013 Feb 14;152(4):703-13. PubMed PMID: 23415221 Gire SK, Stremlau M, Andersen KG, Schaffner SF, Bjornson Z, Rubins K, McCormick J, Lander ES, Garry RF, Happi C, **Sabeti PC**. Emerging Disease or Emerging Diagnosis? *Science* 338 (6108): 750-52. Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, Turnbaugh PJ, Lander ES, Mitzenmacher M, **Sabeti PC**. (2011) Detecting Novel Associations in Large Datasets. *Science* 334(6062):1518-24. PubMed PMID: 22174245; PubMed Central PMCID: PMC3325791 . Grossman SR, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, **Sabeti PC**. (2010) A composite of multiple signals distinguishes causal variants in regions of positive selection. *Science* 327(5967):883-6. PubMed PMID: 20056855. Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr., Johns CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC. (2011) Identification and functional validation of the novel antimalarial resistance locus *PF10\_0355* in *Plasmodium falciparum. PLoS Genetics*2011, in press. Grossman SR, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC. (2010) A composite of multiple signals distinguishes causal variants in regions of positive selection. *Science* 2010, **327**:883-6. Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, et al. Genome-wide detection and characterization of positive selection in human populations.*Nature* 2007,**449**:913-918. Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, et al. Positive natural selection in the human lineage. *Science* 2006,**312**:1614-1620. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, et al. Detecting recent positive selection in the human genome from haplotype structure.*Nature* 2002,**419**:832-837. - ## Building [Northwest Labs](/building/northwest-labs) - ## Lab Group [Sabeti Lab Members](/lab-group/sabeti-lab) - ## People [Faculty](/people/faculty) [Department Faculty](/people/department-faculty) - ## Research Areas [Evolution](/research-areas/evolution) [Infection](/research-areas/infection) [Mathematical & Computational Biology](/research-areas/mathematical-computational-biology) [Population & Evolutionary Genetics](/research-areas/population-and-evolutionary-genetics) - ## Search by Last Name [Q-T](/search-last-name/q-t)